Ubichem Pharma Manufacturing

bulk (100s kg to tons), GMP

manufacturing site: Hungary (EU)

Iminodibenzyl and derivatives

Alfa-Hydroxybenzylphosphinic Acid, Sodium salt

Toldimphos Sodium

2-Azabicyclo(2.2.1)hept-5-en-3-one (racemic and chiral, Vince lactam)

(R)-(-)-2-Chloromandelic Acid

9-Bromo-1-nonanol

R-(+)-1-Phenylethylamine

S-(-)-1-Phenylethylamine

(R)-(-)-Mandelic Acid

(S)-(+)-Mandelic Acid

Optical resolutions High temperature reactions Hydrogenations Acid chloride preparations Carbene additions Diazotizations Friedel-Crafts reactions and isomerizations Cyanations

PRODUCTION UNIT 1

Glass lined reactors from 250L to 12,500L Stainless steel reactors from 4,000L to 8,800L

PRODUCTION UNIT 2

Glass lined reactors from 2,000L to 6,300L 1,000L copper lined reactor (operable up to 300°C)

HYDROGENATION UNIT

Stainless steel hydrogenators from 500L to 1,200L (up to 6 bar)

OTHER EQUIPMENTS

Distillation columns with Sulzer oriented packing up to 400mm x 3m Dryers from 200kg up to 1,000kg capacity Stainless steel centrifuges up to 1,200mm

Ubichem Pharma Services, Ubichem Research g to kg (discovery), GMP

manufacturing site: Hungary (EU)

custom R&D from discovery to manufacture, small scale cGMP API synthesis and radiolabelling

isoquinolines

pyridines

thienopyridines

thienopyrimidines

azaindoles

benzofuropyrimidines

custom research

custom synthesis

radiolabelling

R&D laboratories,

Controlled-access standard synthetic R&D labs, Analytical labs

Class 100,000 cGMP API laboratory

Dedicated Labs for radiolabelling (3H and 14C)

8000m2 Pilot Plant site for larger scale work

with

Process and scale-up lab

Kilo lab

2 main production units

Aaron Chemistry GmbH 
(g to kg)

manufacturing site: Germany (EU)

Acetophenones

Aminoalcohols

Anilines

Aromatics

Azides

Benzaldehydes

Benzoic acids

Benzophenones

Benzyl alcohols

Benzylamines

Benzylhalides

Boronic acids

Chloroacetic Acid Derivatives

Cinnamic Acids

Cyclohexanones

Heterocyclic Acetophenones

Heterocyclic Aldehydes

Heterocyclic Carboxylic Acids

Imidazolidinium Salts

Imidazolium Salts

Isocyanates

Nicotinic Acids

Nitriles

Phenethylamines

Phenoles

Phenylacetic Acids

Phosphor Derivatives

Piperazines

Piperidines

Piperidones

Pyridines

Pyrimidines

Radiopharmaceutical

Precursors

Small Rings

Special Alcohols

Special Aldehydes

Special Amines

Special Carboxylic Acids

Special Ketones

Thioamides

Thiophenes

Unavera ChemLab GmbH

(kg to tons), GMP

manufacturing site: Germany (EU)

Acrylic Acid Derivatives

Benzyl Alcohol Derivatives (and other alcohols)

Benzyl Halides Derivatives

Benzonitriles

Cinnamic Acid Derivatives

Chiral Products

Heterocyclic Acetophenones

Heterocyclic Amines

Heterocyclic/Aromatic Aldehydes

Pyrimidines

Salts (Imidazolium, Imidazolidinium)

Salts (Orotates, Picolinates)

stainless steel, glass and enamel multi purpose reactors from 20 to 1000 liters, with temperature range from +10 °C to +180 °C.

stainless steel reactors from -40 °C to +220°C and pressure up to 9 bar.

Vacuum nutsches separators, pressure filters, hastelloy peeler centrifuges. 

Dryers under normal pressure or vacuum.

All plants and machines can optionally be inertized with nitrogen or argon.

Vinyl Kft. -

industrial bulk

manufacturing site: Hungary (EU)

Periodic Acid

Sodium Metaperiodate

Methyl Iodide

Glass lined and ss reactors from 100 l to 6000 l

Nauta dryers – up to 600 kg

Fractional distillation (up to 3000 l and 24 t.p.)

Hazardous Material handling – chlorine, CS2, hydrazine, azide, triphosgene

Tau-Chem Ltd.

(g to 100s kg (to tons))

manufacturing site: Slovakia (EU)

Epoxides

Furans and benzofurans

Imidazoles and benzimidazoles

Pyridines

Thiophenes

Other heterocycles

Benzenes

Various

Chiral compounds

Aromatics

Glass Reactors (25 l - 100 l)

Glass Stills 100 l and 25 l

Rotatory film evaporator, Molecular Distillation Apparatus (20 Pa)

200 l stainless reactor

250 l glass lined reactor

Büchi high pressure reactor

100 l Jahndorf high pressure reactor

Rotatory evaporator Heidolph Laborota 20

Prosynth Ltd.

10g to 100s kg (to tons)

manufacturing site: United Kingdom (EU)

A wide range of aromatics

boronic acids

silanes

chiral compounds

Cryogenics using liquid Nitrogen and High Pressure Capacity -80°C / +250oC

Hydrogenation Parr to 5L, 3 atom

Distillation: Short path distillation equipment

Georganics 

(g to 100s kg)

manufacturing site: Slovakia (EU)

Benzenes

Furans

Isocyanates

Isothiocyanate

Pyridines

Pyrimidines

Phosphorous compounds

Thiazoles

Thiophenes

K-lab with all common laboratory glass equipment. Pilot plant with:
Glass lined reactors 10-250 l. up to 5 bar or 1 mm vacuum
Centrifuges (batch & continuous)

Rotary Vacuum Dryer
Fractional, steam and vacuum distillers
Crystallization

Continuous thin film evaporator.

Loba Feinchemie AG

(g to tons), cGMP, DMF

manufacturing site: Austria (EU)

Pyridine, quinoline and isoquinoline derivatives

Indoles, triazoles, furanes, and other eterocycles

Chiral amino alcohols, special amino acid derivatives

Aromatic nitro-, amino- and hydrazino compounds

Carboxylic and sulfonic acid derivatives

Aldehydes and ketones and their derivatives

Highly Sensitive Analytical Reagents and Diagnostics

Enzyme substrates

Tetrazolium salts

Nitration, Sulfonation, Chloration, Bromation, Iodination, Alkylation, Acylation, Organo Lithium and Grignard, Oxidation and Reduction including Complex Hydride, Diazotisation and Sandmeyer, Esterification, Saponification, Cyclocondensation

Glass lined vessels from 50 L up to 3000 L

with temperature range from –25 °C to 160 °C.

500 L Stainless Steel Vessel with temperature range from -20 °C to 200 °C.

Halar (ECTFE) coated and Stainless Steel (Alloy 59) Centrifuges, Drying Ovens, Vacuum Drying, Milling Machines, Blenders and Filter Stations

other special products

manufacturing site: Hungary (EU)

Oleum 25% SO₃

Sulphonyl Chloride

Carbodiimides, water and solvent soluble